At a time characterised by profound transitions, including the digital transformation, the Italian Conference of Regions – the institutional platform for coordination among regional authorities – reaffirms its function as a formalised mechanism for dialogue in vertical relations with the Italian Government, Parliament, and the Institutions of the European Union. Within Italy’s consolidated framework of cooperative regionalism, the available legal and institutional sources consistently recognise the Conference’s defined role in multilevel governance, including in the field of technological innovation in public administrations.